PBX3/MEK/ERK1/2/LIN28/let-7b positive feedback loop enhances mesenchymal phenotype to promote glioblastoma migration and invasion

BACKGROUND: Brain invasion by glioblastoma (GBM) determines recurrence and prognosis in patients, which is, in part, attributed to increased mesenchymal transition. Here, we report evidence favoring such a role for the Pre-B-cell leukemia homebox (PBX) family member PBX3. METHODS: Western blot, immu...

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Detalles Bibliográficos
Autores principales: Xu, Xiupeng, Bao, Zhongyuan, Liu, Yinlong, Jiang, Kuan, Zhi, Tongle, Wang, Dong, Fan, Liang, Liu, Ning, Ji, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050701/
https://www.ncbi.nlm.nih.gov/pubmed/30016974
http://dx.doi.org/10.1186/s13046-018-0841-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050701/
https://www.ncbi.nlm.nih.gov/pubmed/30016974
http://dx.doi.org/10.1186/s13046-018-0841-0

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