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Solubility Enhancement of Domperidone by Solvent Change In situ Micronization Technique
BACKGROUND: Domperidone (DOM), a dopamine receptor antagonist, is used as antiemetic for the treatment of gastroparesis, vomiting, and nausea. The low water solubility of DOM leads to a low dissolution rate and variable bioavailability. The aim of this study was to enhance the solubility of DOM by t...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Medknow Publications & Media Pvt Ltd
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050975/ https://www.ncbi.nlm.nih.gov/pubmed/30069440 http://dx.doi.org/10.4103/abr.abr_219_17 |