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Chromosomes trapped in micronuclei are liable to segregation errors

DNA in micronuclei is likely to get damaged. When shattered DNA from micronuclei gets reincorporated into the primary nucleus, aberrant rearrangements can take place, a phenomenon referred to as chromothripsis. Here, we investigated how chromatids from micronuclei act in subsequent divisions and how...

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Detalles Bibliográficos
Autores principales: Soto, Mar, García-Santisteban, Iraia, Krenning, Lenno, Medema, René H., Raaijmakers, Jonne A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6051344/
https://www.ncbi.nlm.nih.gov/pubmed/29930083
http://dx.doi.org/10.1242/jcs.214742