Amino acid deprivation triggers a novel GCN2-independent response leading to the transcriptional reactivation of non-native DNA sequences

In a variety of species, reduced food intake, and in particular protein or amino acid (AA) restriction, extends lifespan and healthspan. However, the underlying epigenetic and/or transcriptional mechanisms are largely unknown, and dissection of specific pathways in cultured cells may contribute to f...

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Detalles Bibliográficos
Autores principales: De Vito, Annarosaria, Lazzaro, Massimo, Palmisano, Ilaria, Cittaro, Davide, Riba, Michela, Lazarevic, Dejan, Bannai, Makoto, Gabellini, Davide, Schiaffino, Maria Vittoria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6051655/
https://www.ncbi.nlm.nih.gov/pubmed/30020994
http://dx.doi.org/10.1371/journal.pone.0200783

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6051655/
https://www.ncbi.nlm.nih.gov/pubmed/30020994
http://dx.doi.org/10.1371/journal.pone.0200783

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