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Aspartate is an endogenous metabolic limitation for tumour growth
Defining the metabolic limitations of tumour growth will help develop cancer therapies(1). Cancer cells proliferate slower in tumours than in standard culture conditions, indicating that a metabolic limitation may restrict cell proliferation in vivo. Aspartate synthesis can limit cancer cell prolife...
Autores principales: | Sullivan, Lucas B., Luengo, Alba, Danai, Laura V., Bush, Lauren N., Diehl, Frances F., Hosios, Aaron M., Lau, Allison N., Elmiligy, Sarah, Malstrom, Scott, Lewis, Caroline A., Vander Heiden, Matthew G. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6051729/ https://www.ncbi.nlm.nih.gov/pubmed/29941931 http://dx.doi.org/10.1038/s41556-018-0125-0 |
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