Kinome rewiring reveals AURKA limits PI3K-pathway inhibitor efficacy in breast cancer

Dysregulation of the PI3K-AKT-mTOR signaling network is a prominent feature of breast cancers. However, clinical responses to drugs targeting this pathway have been modest, possibly due to dynamic changes in cellular signaling that drive resistance and limit drug efficacy. Using a quantitative chemo...

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Detalles Bibliográficos
Autores principales: Donnella, Hayley J, Webber, James T, Levin, Rebecca S, Camarda, Roman, Momcilovic, Olga, Bayani, Nora, Shah, Khyati N, Korkola, James, Shokat, Kevan M, Goga, Andrei, Gordan, John D, Bandyopadhyay, Sourav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6051919/
https://www.ncbi.nlm.nih.gov/pubmed/29942081
http://dx.doi.org/10.1038/s41589-018-0081-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6051919/
https://www.ncbi.nlm.nih.gov/pubmed/29942081
http://dx.doi.org/10.1038/s41589-018-0081-9

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