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Kinome rewiring reveals AURKA limits PI3K-pathway inhibitor efficacy in breast cancer
Dysregulation of the PI3K-AKT-mTOR signaling network is a prominent feature of breast cancers. However, clinical responses to drugs targeting this pathway have been modest, possibly due to dynamic changes in cellular signaling that drive resistance and limit drug efficacy. Using a quantitative chemo...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6051919/ https://www.ncbi.nlm.nih.gov/pubmed/29942081 http://dx.doi.org/10.1038/s41589-018-0081-9 |