p38-mediated phosphorylation at T367 induces EZH2 cytoplasmic localization to promote breast cancer metastasis

Overexpression of EZH2 in estrogen receptor negative (ER-) breast cancer promotes metastasis. EZH2 has been mainly studied as the catalytic component of the Polycomb Repressive Complex 2 (PRC2) that mediates gene repression by trimethylating histone H3 at lysine 27 (H3K27me3). However, how EZH2 driv...

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Detalles Bibliográficos
Autores principales: Anwar, Talha, Arellano-Garcia, Caroline, Ropa, James, Chen, Yu-Chih, Kim, Hong Sun, Yoon, Euisik, Grigsby, Sierrah, Basrur, Venkatesha, Nesvizhskii, Alexey I., Muntean, Andrew, Gonzalez, Maria E., Kidwell, Kelley M., Nikolovska-Coleska, Zaneta, Kleer, Celina G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6051995/
https://www.ncbi.nlm.nih.gov/pubmed/30022044
http://dx.doi.org/10.1038/s41467-018-05078-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6051995/
https://www.ncbi.nlm.nih.gov/pubmed/30022044
http://dx.doi.org/10.1038/s41467-018-05078-8

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