Cargando…

Triptolide attenuates proteinuria and podocyte apoptosis via inhibition of NF-κB/GADD45B

Podocyte injury is a primary contributor to proteinuria. Triptolide is a major active component of Tripterygium wilfordii Hook F that exhibits potent antiproteinuric effects. We used our previously developed in vivo zebrafish model of inducible podocyte-target injury and found that triptolide treatm...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Ling, Zhang, Liwen, Hou, Qing, Zhu, Xiaodong, Chen, Zhaohong, Liu, Zhihong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6052061/ https://www.ncbi.nlm.nih.gov/pubmed/30022148 http://dx.doi.org/10.1038/s41598-018-29203-1

Ejemplares similares

GADD45B mediates podocyte injury in zebrafish by activating the ROS-GADD45B-p38 pathway
por: Chen, Z, et al.
Publicado: (2016)

Triptolide ameliorates fine particulate matter-induced podocytes injury via regulating NF-κB signaling pathway
por: Wan, Qiang, et al.
Publicado: (2020)

Cancer-Selective Targeting of the NF-κB Survival Pathway with GADD45β/MKK7 Inhibitors
por: Tornatore, Laura, et al.
Publicado: (2014)

Cancer-Selective Targeting of the NF-κB Survival Pathway with GADD45β/MKK7 Inhibitors
por: Tornatore, Laura, et al.
Publicado: (2014)

Lipopolysaccharide Enhances Genotoxicity by Activating GADD45G and NF-κB in Human Corneal Epithelial Cells
por: Samivel, Ramachandran, et al.
Publicado: (2022)

GADD45a and GADD45b Genes in Rheumatoid Arthritis and Systemic Lupus Erythematosus Patients
por: Li, Ruei-Nian, et al.
Publicado: (2019)

NF-κB mediates Gadd45β expression and DNA demethylation in the hippocampus during fear memory formation
por: Jarome, Timothy J., et al.
Publicado: (2015)

Gadd45b is a Novel Mediator of Neuronal Apoptosis in Ischemic Stroke
por: Liu, Bin, et al.
Publicado: (2015)

GADD45A and GADD45B as Novel Biomarkers Associated with Chromatin Regulators in Renal Ischemia-Reperfusion Injury
por: Xie, Ming, et al.
Publicado: (2023)

Triptolide attenuates lipopolysaccharide-induced inflammatory responses in human endothelial cells: involvement of NF-κB pathway
por: Song, Chundong, et al.
Publicado: (2019)

Gadd45β and Gadd45γ are critical for regulating autoimmunity
por: Liu, Lin, et al.
Publicado: (2005)

The Antigastric Cancer Effect of Triptolide is Associated With H19/NF-κB/FLIP Axis
por: Yuan, Weiwei, et al.
Publicado: (2022)

Abnormal expression of GADD45B in human colorectal carcinoma
por: Wang, Lisha, et al.
Publicado: (2012)

The role of Gadd45b in neurologic and neuropsychiatric disorders: An overview
por: Shen, Xiao-yue, et al.
Publicado: (2022)

Role of the podocyte in proteinuria
por: Menzel, Sylvia, et al.
Publicado: (2011)

A new perspective of triptolide-associated hepatotoxicity: the relevance of NF-κB and NF-κB-mediated cellular FLICE-inhibitory protein
por: Yuan, Ziqiao, et al.
Publicado: (2020)

Triptolide markedly attenuates albuminuria and podocyte injury in an animal model of diabetic nephropathy
por: MA, RUIXIA, et al.
Publicado: (2013)

Gadd45b deficiency promotes premature senescence and skin aging
por: Magimaidas, Andrew, et al.
Publicado: (2016)

Loss of Gadd45b accelerates BCR-ABL-driven CML
por: Sha, Xiaojin, et al.
Publicado: (2018)

Regulation of dopamine-dependent transcription and cocaine action by Gadd45b
por: Zipperly, Morgan E., et al.
Publicado: (2020)

Double-edged Gadd45
por: Powell, Kendall
Publicado: (2005)

Gadd45 in stress signaling
por: Liebermann, Dan A, et al.
Publicado: (2008)

Triptolide Transcriptionally Represses HER2 in Ovarian Cancer Cells by Targeting NF-κB
por: Ou, Chien-Chih, et al.
Publicado: (2012)

Triptolide Combined with Radiotherapy for the Treatment of Nasopharyngeal Carcinoma via NF-κB-Related Mechanism
por: Zhang, Weiying, et al.
Publicado: (2016)

Triptolide reverses the Taxol resistance of lung adenocarcinoma by inhibiting the NF-κB signaling pathway and the expression of NF-κB-regulated drug-resistant genes
por: JIANG, NING, et al.
Publicado: (2016)

Ribosomal protein S7 regulates arsenite-induced GADD45α expression by attenuating MDM2-mediated GADD45α ubiquitination and degradation
por: Gao, Ming, et al.
Publicado: (2013)

Role of D-GADD45 in JNK-Dependent Apoptosis and Regeneration in Drosophila
por: Camilleri-Robles, Carlos, et al.
Publicado: (2019)

Gadd45b mediates depressive-like role through DNA demethylation
por: Labonté, Benoit, et al.
Publicado: (2019)

Non-canonical NFκB activation promotes chemokine expression in podocytes
por: Valiño-Rivas, Lara, et al.
Publicado: (2016)

Podocyte NF‐κB is dispensable for the pathogenesis of renal ischemia‐reperfusion injury
por: Yamashita, Maho, et al.
Publicado: (2016)

IKKβ programs to turn on the GADD45α–MKK4–JNK apoptotic cascade specifically via p50 NF-κB in arsenite response
por: Song, Lun, et al.
Publicado: (2006)

GADD45B as a Prognostic and Predictive Biomarker in Stage II Colorectal Cancer
por: Zhao, Zhixun, et al.
Publicado: (2018)

Gadd45b Acts as Neuroprotective Effector in Global Ischemia-Induced Neuronal Death
por: Cho, Chang Hoon, et al.
Publicado: (2019)

GADD45B Facilitates Metastasis of Ovarian Cancer Through Epithelial–Mesenchymal Transition
por: Gong, Lanqing, et al.
Publicado: (2021)

Triptolide protects podocytes via autophagy in immunoglobulin A nephropathy
por: Liang, Shikai, et al.
Publicado: (2018)

Genetic variants of GADD45A, GADD45B and MAPK14 predict platinum-based chemotherapy-induced toxicities in Chinese patients with non-small cell lung cancer
por: Jia, Ming, et al.
Publicado: (2016)

Gadd45 stress sensors in suppression of leukemia
por: Wiest, David L.
Publicado: (2018)

Triptolide Attenuates Podocyte Injury by Regulating Expression of miRNA-344b-3p and miRNA-30b-3p in Rats with Adriamycin-Induced Nephropathy
por: Jiang, Chun-Bo, et al.
Publicado: (2015)

Protein tyrosine phosphatase Shp2 deficiency in podocytes attenuates lipopolysaccharide-induced proteinuria
por: Hsu, Ming-Fo, et al.
Publicado: (2017)

Triptolide Inhibits Invasion and Tumorigenesis of Hepatocellular Carcinoma MHCC-97H Cells Through NF-κB Signaling
por: Wang, Haiji, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_kf9vh58v85i809amllhme4r9lp