MDC1 methylation mediated by lysine methyltransferases EHMT1 and EHMT2 regulates active ATM accumulation flanking DNA damage sites

Chromatin dynamics mediated by post-translational modifications play a crucial role in cellular response to genotoxic stress for the maintenance of genome integrity. MDC1 is a pivotal chromatin adaptor in DNA damage response (DDR) and its methylation is essential to recruit repair factors at DNA dou...

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Detalles Bibliográficos
Autores principales: Watanabe, Sugiko, Iimori, Makoto, Chan, David Virya, Hara, Eiji, Kitao, Hiroyuki, Maehara, Yoshihiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6052104/
https://www.ncbi.nlm.nih.gov/pubmed/30022091
http://dx.doi.org/10.1038/s41598-018-29239-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6052104/
https://www.ncbi.nlm.nih.gov/pubmed/30022091
http://dx.doi.org/10.1038/s41598-018-29239-3

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