Selective inhibition of carbonic anhydrase-IX by sulphonamide derivatives induces pH and reactive oxygen species-mediated apoptosis in cervical cancer HeLa cells

Selective inhibition with sulphonamides of carbonic anhydrase (CA) IX reduces cell proliferation and induces apoptosis in human cancer cells. The effect on CA IX expression of seven previously synthesised sulphonamide inhibitors, with high affinity for CA IX, as well as their effect on the prolifera...

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Detalles Bibliográficos
Autores principales: Koyuncu, Ismail, Gonel, Ataman, Kocyigit, Abdurrahim, Temiz, Ebru, Durgun, Mustafa, Supuran, Claudiu T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6052416/
https://www.ncbi.nlm.nih.gov/pubmed/30001631
http://dx.doi.org/10.1080/14756366.2018.1481403

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6052416/
https://www.ncbi.nlm.nih.gov/pubmed/30001631
http://dx.doi.org/10.1080/14756366.2018.1481403

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