Metformin alleviates human cellular aging by upregulating the endoplasmic reticulum glutathione peroxidase 7

Metformin, an FDA‐approved antidiabetic drug, has been shown to elongate lifespan in animal models. Nevertheless, the effects of metformin on human cells remain unclear. Here, we show that low‐dose metformin treatment extends the lifespan of human diploid fibroblasts and mesenchymal stem cells. We r...

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Detalles Bibliográficos
Autores principales: Fang, Jingqi, Yang, Jiping, Wu, Xun, Zhang, Gangming, Li, Tao, Wang, Xi'e, Zhang, Hong, Wang, Chih‐chen, Liu, Guang‐Hui, Wang, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6052468/
https://www.ncbi.nlm.nih.gov/pubmed/29659168
http://dx.doi.org/10.1111/acel.12765

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6052468/
https://www.ncbi.nlm.nih.gov/pubmed/29659168
http://dx.doi.org/10.1111/acel.12765

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