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Acute tau knockdown in the hippocampus of adult mice causes learning and memory deficits

Misfolded and hyperphosphorylated tau accumulates in several neurodegenerative disorders including Alzheimer's disease, frontotemporal dementia with Parkinsonism, corticobasal degeneration, progressive supranuclear palsy, Down syndrome, and Pick's disease. Tau is a microtubule‐binding prot...

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Detalles Bibliográficos
Autores principales: Velazquez, Ramon, Ferreira, Eric, Tran, An, Turner, Emily C., Belfiore, Ramona, Branca, Caterina, Oddo, Salvatore
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6052471/
https://www.ncbi.nlm.nih.gov/pubmed/29749079
http://dx.doi.org/10.1111/acel.12775