Carbonic anhydrase inhibition selectively prevents amyloid β neurovascular mitochondrial toxicity

Mounting evidence suggests that mitochondrial dysfunction plays a causal role in the etiology and progression of Alzheimer's disease (AD). We recently showed that the carbonic anhydrase inhibitor (CAI) methazolamide (MTZ) prevents amyloid β (Aβ)‐mediated onset of apoptosis in the mouse brain. I...

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Detalles Bibliográficos
Autores principales: Solesio, María E., Peixoto, Pablo M., Debure, Ludovic, Madamba, Stephen M., de Leon, Mony J., Wisniewski, Thomas, Pavlov, Evgeny V., Fossati, Silvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6052473/
https://www.ncbi.nlm.nih.gov/pubmed/29873184
http://dx.doi.org/10.1111/acel.12787

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6052473/
https://www.ncbi.nlm.nih.gov/pubmed/29873184
http://dx.doi.org/10.1111/acel.12787

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