Mitochondrial unfolded protein response gene Clpp is required to maintain ovarian follicular reserve during aging, for oocyte competence, and development of pre‐implantation embryos

Caseinolytic peptidase P mediates degradation of unfolded mitochondrial proteins and activates mitochondrial unfolded protein response (mtUPR) to maintain protein homeostasis. Clpp (−/−) female mice generate a lower number of mature oocytes and two‐cell embryos, and no blastocysts. Clpp (−/−) oocyte...

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Detalles Bibliográficos
Autores principales: Wang, Tianren, Babayev, Elnur, Jiang, Zongliang, Li, Guangxin, Zhang, Man, Esencan, Ecem, Horvath, Tamas, Seli, Emre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6052477/
https://www.ncbi.nlm.nih.gov/pubmed/29851234
http://dx.doi.org/10.1111/acel.12784

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6052477/
https://www.ncbi.nlm.nih.gov/pubmed/29851234
http://dx.doi.org/10.1111/acel.12784

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