Benchmarking differential expression analysis tools for RNA-Seq: normalization-based vs. log-ratio transformation-based methods

BACKGROUND: Count data generated by next-generation sequencing assays do not measure absolute transcript abundances. Instead, the data are constrained to an arbitrary “library size” by the sequencing depth of the assay, and typically must be normalized prior to statistical analysis. The constrained...

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Detalles Bibliográficos
Autores principales: Quinn, Thomas P., Crowley, Tamsyn M., Richardson, Mark F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6052553/
https://www.ncbi.nlm.nih.gov/pubmed/30021534
http://dx.doi.org/10.1186/s12859-018-2261-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6052553/
https://www.ncbi.nlm.nih.gov/pubmed/30021534
http://dx.doi.org/10.1186/s12859-018-2261-8

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