Defective Base Excision Repair of Oxidative DNA Damage in Vascular Smooth Muscle Cells Promotes Atherosclerosis

BACKGROUND: Atherosclerotic plaques demonstrate extensive accumulation of oxidative DNA damage, predominantly as 8-oxoguanine (8oxoG) lesions. 8oxoG is repaired by base excision repair enzymes; however, the mechanisms regulating 8oxoG accumulation in vascular smooth muscle cells (VSMCs) and its effe...

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Detalles Bibliográficos
Autores principales: Shah, Aarti, Gray, Kelly, Figg, Nichola, Finigan, Alison, Starks, Lakshi, Bennett, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2018
Materias:
Original Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053042/
https://www.ncbi.nlm.nih.gov/pubmed/29643057
http://dx.doi.org/10.1161/CIRCULATIONAHA.117.033249

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053042/
https://www.ncbi.nlm.nih.gov/pubmed/29643057
http://dx.doi.org/10.1161/CIRCULATIONAHA.117.033249

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