Missing single nucleotide polymorphisms in Genetic Risk Scores: A simulation study

Using a genetic risk score (GRS) to predict a phenotype in a target sample can be complicated by missing data on the single nucleotide polymorphisms (SNPs) that comprise the GRS. This is usually addressed by imputation, omission of the SNPs or by replacing the missing SNPs with proxy SNPs. To assess...

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Detalles Bibliográficos
Autores principales: Chagnon, Miguel, O’Loughlin, Jennifer, Engert, James C., Karp, Igor, Sylvestre, Marie-Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053141/
https://www.ncbi.nlm.nih.gov/pubmed/30024900
http://dx.doi.org/10.1371/journal.pone.0200630

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053141/
https://www.ncbi.nlm.nih.gov/pubmed/30024900
http://dx.doi.org/10.1371/journal.pone.0200630

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