Modeling APC mutagenesis and familial adenomatous polyposis using human iPS cells

Mutations in the gene Adenomatous Polyposis Coli or APC appear in most sporadic cases of colorectal cancer and it is the most frequent mutation causing hereditary Familial Adenomatous Polyposis. The detailed molecular mechanism by which APC mutations predispose to the development of colorectal cance...

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Detalles Bibliográficos
Autores principales: Sommer, Cesar A., Capilla, Amalia, Molina-Estevez, Francisco J., Gianotti-Sommer, Andreia, Skvir, Nicholas, Caballero, Ignacio, Chowdhury, Sanjib, Mostoslavsky, Gustavo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053155/
https://www.ncbi.nlm.nih.gov/pubmed/30024920
http://dx.doi.org/10.1371/journal.pone.0200657

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053155/
https://www.ncbi.nlm.nih.gov/pubmed/30024920
http://dx.doi.org/10.1371/journal.pone.0200657

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