CCR8 is expressed by post-positive selection CD4-lineage thymocytes but is dispensable for central tolerance induction

Following positive selection, thymocytes migrate into the medulla where they encounter diverse self-antigens that induce central tolerance. Thymocytes expressing T cell receptors (TCRs) with high affinity for self-antigens displayed by medullary antigen presenting cells (APCs) undergo either negativ...

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Detalles Bibliográficos
Autores principales: Thyagarajan, Hiran M., Lancaster, Jessica N., Lira, Sergio A., Ehrlich, Lauren I. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053179/
https://www.ncbi.nlm.nih.gov/pubmed/30024927
http://dx.doi.org/10.1371/journal.pone.0200765

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053179/
https://www.ncbi.nlm.nih.gov/pubmed/30024927
http://dx.doi.org/10.1371/journal.pone.0200765

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