miR-122 inhibition in a human liver organoid model leads to liver inflammation, necrosis, steatofibrosis and dysregulated insulin signaling

To investigate the role of miR-122 in the development and regression of non-alcoholic fatty liver disease (NAFLD) in vitro, we used multicellular 3D human liver organoids developed in our laboratory. These organoids consist of primary human hepatocytes, Kupffer cells, quiescent stellate cells and li...

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Detalles Bibliográficos
Autores principales: Sendi, Hossein, Mead, Ivy, Wan, Meimei, Mehrab-Mohseni, Marjan, Koch, Kenneth, Atala, Anthony, Bonkovsky, Herbert L., Bishop, Colin E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053181/
https://www.ncbi.nlm.nih.gov/pubmed/30024933
http://dx.doi.org/10.1371/journal.pone.0200847

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053181/
https://www.ncbi.nlm.nih.gov/pubmed/30024933
http://dx.doi.org/10.1371/journal.pone.0200847

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