Modeling the role of microRNA-449a in the regulation of the G2/M cell cycle checkpoint in prostate LNCaP cells under ionizing radiation

Recent studies showed that induced microRNA-449a (miR-449a) enhances a G2/M cell cycle checkpoint arrest in prostate cancer (LNCaP) and lung adenocarcinoma cell lines. In the case of LNCaP cells, upregulated miR-449a directly downregulates c-Myc that is required to induce the cell cycle regulators C...

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Detalles Bibliográficos
Autores principales: Gupta, Shantanu, Silveira, Daner A., Mombach, José Carlos M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053189/
https://www.ncbi.nlm.nih.gov/pubmed/30024932
http://dx.doi.org/10.1371/journal.pone.0200768

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053189/
https://www.ncbi.nlm.nih.gov/pubmed/30024932
http://dx.doi.org/10.1371/journal.pone.0200768

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