Tyrosine 870 of TLR9 is critical for receptor maturation rather than phosphorylation-dependent ligand-induced signaling

Toll like receptors (TLRs) share a conserved structure comprising the N-terminal ectodomain, a transmembrane segment and a C-terminal cytoplasmic Toll/IL-1 receptor (TIR) domain. Proper assembly of the TIR domain is crucial for signal transduction; however, the contribution of individual motifs with...

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Detalles Bibliográficos
Autores principales: Biswas, Chhanda, Rao, Sheila, Slade, Katharine, Hyman, David, Dersh, Devin, Mantegazza, Adriana R., Zoltick, Philip W., Marks, Michael S., Argon, Yair, Behrens, Edward M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053202/
https://www.ncbi.nlm.nih.gov/pubmed/30024926
http://dx.doi.org/10.1371/journal.pone.0200913

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053202/
https://www.ncbi.nlm.nih.gov/pubmed/30024926
http://dx.doi.org/10.1371/journal.pone.0200913

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