The major β-catenin/E-cadherin junctional binding site is a primary molecular mechano-transductor of differentiation in vivo

In vivo, the primary molecular mechanotransductive events mechanically initiating cell differentiation remain unknown. Here we find the molecular stretching of the highly conserved Y654-β-catenin-D665-E-cadherin binding site as mechanically induced by tissue strain. It triggers the increase of acces...

Descripción completa

Detalles Bibliográficos
Autores principales: Röper, Jens-Christian, Mitrossilis, Démosthène, Stirnemann, Guillaume, Waharte, François, Brito, Isabel, Fernandez-Sanchez, Maria-Elena, Baaden, Marc, Salamero, Jean, Farge, Emmanuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053302/
https://www.ncbi.nlm.nih.gov/pubmed/30024850
http://dx.doi.org/10.7554/eLife.33381

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053302/
https://www.ncbi.nlm.nih.gov/pubmed/30024850
http://dx.doi.org/10.7554/eLife.33381

Ejemplares similares