Inhibiting the integrated stress response pathway prevents aberrant chondrocyte differentiation thereby alleviating chondrodysplasia

The integrated stress response (ISR) is activated by diverse forms of cellular stress, including endoplasmic reticulum (ER) stress, and is associated with diseases. However, the molecular mechanism(s) whereby the ISR impacts on differentiation is incompletely understood. Here, we exploited a mouse m...

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Detalles Bibliográficos
Autores principales: Wang, Cheng, Tan, Zhijia, Niu, Ben, Tsang, Kwok Yeung, Tai, Andrew, Chan, Wilson C W, Lo, Rebecca L K, Leung, Keith K H, Dung, Nelson W F, Itoh, Nobuyuki, Zhang, Michael Q, Chan, Danny, Cheah, Kathryn Song Eng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053305/
https://www.ncbi.nlm.nih.gov/pubmed/30024379
http://dx.doi.org/10.7554/eLife.37673

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053305/
https://www.ncbi.nlm.nih.gov/pubmed/30024379
http://dx.doi.org/10.7554/eLife.37673

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