Epicutaneous administration of the pattern recognition receptor agonist polyinosinic–polycytidylic acid activates the MDA5/MAVS pathway in Langerhans cells

Together with keratinocytes (KCs) and the dense network of Langerhans cells (LCs), the epidermis is an ideal portal for vaccine delivery. Pattern recognition receptor agonists, in particular polyinosinic–polycytidylic acid [p(I:C)], are promising adjuvant candidates for therapeutic vaccination to ge...

Descripción completa

Detalles Bibliográficos
Autores principales: Tajpara, Pooja, Schuster, Christopher, Schön, Elisabeth, Kienzl, Philip, Vierhapper, Martin, Mildner, Michael, Elbe-Bürger, Adelheid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Federation of American Societies for Experimental Biology 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053315/
https://www.ncbi.nlm.nih.gov/pubmed/29509510
http://dx.doi.org/10.1096/fj.201701090R

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053315/
https://www.ncbi.nlm.nih.gov/pubmed/29509510
http://dx.doi.org/10.1096/fj.201701090R

Ejemplares similares