Comprehensive map of age-associated splicing changes across human tissues and their contributions to age-associated diseases

Alternative splicing contributes to phenotypic diversity at multiple biological scales, and its dysregulation is implicated in both ageing and age-associated diseases in human. Cross-tissue variability in splicing further complicates its links to age-associated phenotypes and elucidating these links...

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Detalles Bibliográficos
Autores principales: Wang, Kun, Wu, Di, Zhang, Haoyue, Das, Avinash, Basu, Mahashweta, Malin, Justin, Cao, Kan, Hannenhalli, Sridhar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053367/
https://www.ncbi.nlm.nih.gov/pubmed/30026530
http://dx.doi.org/10.1038/s41598-018-29086-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053367/
https://www.ncbi.nlm.nih.gov/pubmed/30026530
http://dx.doi.org/10.1038/s41598-018-29086-2

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