Novel 2-phenyloxypyrimidine derivative induces apoptosis and autophagy via inhibiting PI3K pathway and activating MAPK/ERK signaling in hepatocellular carcinoma cells

Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related mortality globally. Because most patients are diagnosed at advanced stages of the disease, multi-targeted tyrosine kinase inhibitor sorafenib is the only available drug to show limited effectiveness. Novel and effective the...

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Detalles Bibliográficos
Autores principales: Wang, Jing, Sun, Peng, Chen, Yijun, Yao, Hequan, Wang, Shuzhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053381/
https://www.ncbi.nlm.nih.gov/pubmed/30026540
http://dx.doi.org/10.1038/s41598-018-29199-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053381/
https://www.ncbi.nlm.nih.gov/pubmed/30026540
http://dx.doi.org/10.1038/s41598-018-29199-8

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