Eplerenone Reverses Cardiac Fibrosis via the Suppression of Tregs by Inhibition of Kv1.3 Channel

Background: Fibroblast proliferation is a critical feature during heart failure development. Previous studies reported regulatory T-lymphocytes (Tregs)’ protective role against myocardial fibrosis. However, notably, Tregs also secrete fibrogenic cytokine TGF-β when activated. This study aimed to cla...

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Detalles Bibliográficos
Autores principales: Shao, Pei-Pei, Liu, Chang-Jiang, Xu, Qi, Zhang, Bo, Li, Shao-Hua, Wu, Yang, Sun, Zhan, Cheng, Lu-Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053534/
https://www.ncbi.nlm.nih.gov/pubmed/30057554
http://dx.doi.org/10.3389/fphys.2018.00899

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053534/
https://www.ncbi.nlm.nih.gov/pubmed/30057554
http://dx.doi.org/10.3389/fphys.2018.00899

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