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Eplerenone Reverses Cardiac Fibrosis via the Suppression of Tregs by Inhibition of Kv1.3 Channel

Background: Fibroblast proliferation is a critical feature during heart failure development. Previous studies reported regulatory T-lymphocytes (Tregs)’ protective role against myocardial fibrosis. However, notably, Tregs also secrete fibrogenic cytokine TGF-β when activated. This study aimed to cla...

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Detalles Bibliográficos
Autores principales:	Shao, Pei-Pei, Liu, Chang-Jiang, Xu, Qi, Zhang, Bo, Li, Shao-Hua, Wu, Yang, Sun, Zhan, Cheng, Lu-Feng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Physiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053534/ https://www.ncbi.nlm.nih.gov/pubmed/30057554 http://dx.doi.org/10.3389/fphys.2018.00899

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