Gram scale preparation of clozapine N-oxide (CNO), a synthetic small molecule actuator for muscarinic acetylcholine DREADDs

Chemogenetics uses engineered proteins that are controlled by small molecule actuators, allowing in vivo functional studies of proteins with temporal and dose control, and include Designer Receptors Exclusively Activated by Designer Drugs (DREADDs). One major class of DREADDs are mutated muscarinic...

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Detalles Bibliográficos
Autores principales: van der Peet, Phillip L., Gunawan, Christian, Abdul-Ridha, Alaa, Ma, Sherie, Scott, Daniel J., Gundlach, Andrew L., Bathgate, Ross A.D., White, Jonathan M., Williams, Spencer J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Pharmacology, Toxicology and Pharmaceutical Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053635/
https://www.ncbi.nlm.nih.gov/pubmed/30038895
http://dx.doi.org/10.1016/j.mex.2018.03.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053635/
https://www.ncbi.nlm.nih.gov/pubmed/30038895
http://dx.doi.org/10.1016/j.mex.2018.03.003

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