Consumption of NADPH for 2-HG Synthesis Increases Pentose Phosphate Pathway Flux and Sensitizes Cells to Oxidative Stress

Gain-of-function mutations in isocitrate dehydroge-nase 1 (IDH1) occur in multiple types of human cancer. Here, we show that these mutations significantly disrupt NADPH homeostasis by consuming NADPH for 2-hydroxyglutarate (2-HG) synthesis. Cells respond to 2-HG synthesis, but not exogenous administ...

Descripción completa

Detalles Bibliográficos
Autores principales: Gelman, Susan J., Naser, Fuad, Mahieu, Nathaniel G., McKenzie, Lisa D., Dunn, Gavin P., Chheda, Milan G., Patti, Gary J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053654/
https://www.ncbi.nlm.nih.gov/pubmed/29320744
http://dx.doi.org/10.1016/j.celrep.2017.12.050

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053654/
https://www.ncbi.nlm.nih.gov/pubmed/29320744
http://dx.doi.org/10.1016/j.celrep.2017.12.050

Ejemplares similares