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Tumoral BRD4 expression in lymph node-negative breast cancer: association with T-bet+ tumor-infiltrating lymphocytes and disease-free survival

BACKGROUND: We previously observed that T-bet+ tumor-infiltrating T lymphocytes (T-bet+ TILs) in primary breast tumors were associated with adverse clinicopathological features, yet favorable clinical outcome. We identified BRD4 (Bromodomain-Containing Protein 4), a member of the  Bromodomain and Ex...

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Detalles Bibliográficos
Autores principales: Lee, Minji, Tayyari, Farnoosh, Pinnaduwage, Dushanthi, Bayani, Jane, Bartlett, John M. S., Mulligan, Anna Marie, Bull, Shelley B., Andrulis, Irene L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053709/
https://www.ncbi.nlm.nih.gov/pubmed/30029633
http://dx.doi.org/10.1186/s12885-018-4653-6