Control of cytokine mRNA degradation by the histone deacetylase inhibitor ITF2357 in rheumatoid arthritis fibroblast-like synoviocytes: beyond transcriptional regulation

BACKGROUND: Histone deacetylase inhibitors (HDACi) suppress cytokine production in immune and stromal cells of patients with rheumatoid arthritis (RA). Here, we investigated the effects of the HDACi givinostat (ITF2357) on the transcriptional and post-transcriptional regulation of inflammatory marke...

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Detalles Bibliográficos
Autores principales: Angiolilli, Chiara, Kabala, Pawel A., Grabiec, Aleksander M., Rossato, Marzia, Lai, Wi S., Fossati, Gianluca, Mascagni, Paolo, Steinkühler, Christian, Blackshear, Perry J., Reedquist, Kris A., Baeten, Dominique L., Radstake, Timothy R. D. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053802/
https://www.ncbi.nlm.nih.gov/pubmed/30029685
http://dx.doi.org/10.1186/s13075-018-1638-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053802/
https://www.ncbi.nlm.nih.gov/pubmed/30029685
http://dx.doi.org/10.1186/s13075-018-1638-4

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