Cargando…

Sarpagan bridge enzyme has substrate-controlled cyclization and aromatization modes

Cyclization reactions that create complex polycyclic scaffolds are hallmarks of alkaloid biosynthetic pathways. We present the discovery of three homologous cytochromes P450 from three monoterpene indole alkaloid-producing plants (Rauwolfia serpentina, Gelsemium sempervirens and Catharanthus roseus)...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dang, Thu-Thuy T, Franke, Jakob, Teto Carqueijeiro, Inês Soares, Langley, Chloe, Courdavault, Vincent, O’Connor, Sarah E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054303/ https://www.ncbi.nlm.nih.gov/pubmed/29942076 http://dx.doi.org/10.1038/s41589-018-0078-4

Ejemplares similares

A three enzyme system to generate the Strychnos alkaloid scaffold from a central biosynthetic intermediate
por: Tatsis, Evangelos C., et al.
Publicado: (2017)

Dual Catalytic Activity of a Cytochrome P450 Controls Bifurcation at a Metabolic Branch Point of Alkaloid Biosynthesis in Rauwolfia serpentina
por: Dang, Thu‐Thuy T., et al.
Publicado: (2017)

Conversion of Substrate Analogs Suggests a Michael Cyclization in Iridoid Biosynthesis
por: Lindner, Stephanie, et al.
Publicado: (2014)

Cannabidiol as the Substrate in Acid-Catalyzed Intramolecular Cyclization
por: Marzullo, Paola, et al.
Publicado: (2020)

Editorial: Exploring and Engineering Plant Specialized Metabolism: Latest Advances and New Horizons
por: Franke, Jakob, et al.
Publicado: (2021)

Post-Cyclization Skeletal Rearrangements in Plant Triterpenoid Biosynthesis by a Pair of Branchpoint Isomerases
por: Chuang, Ling, et al.
Publicado: (2023)

ASBAAC: Automated Salt-Bridge and Aromatic-Aromatic Calculator
por: Roy, Chittran, et al.
Publicado: (2018)

An NPF Transporter Exports a Central Monoterpene Indole Alkaloid Intermediate from the Vacuole
por: Payne, Richard M. E., et al.
Publicado: (2017)

Thiyl Radicals: Versatile Reactive Intermediates for Cyclization of Unsaturated Substrates
por: Lynch, Dylan M., et al.
Publicado: (2020)

Synthesis of stable polymetalated aromatic complexes through metal–macrocycle capsule-triggered cyclization
por: He, Xin, et al.
Publicado: (2017)

Recent Advances in Substrate-Controlled Asymmetric Cyclization for Natural Product Synthesis
por: Jo, Jeyun, et al.
Publicado: (2017)

Marine Bacterial Aromatic Polyketides From Host-Dependent Heterologous Expression and Fungal Mode of Cyclization
por: Huang, Chunshuai, et al.
Publicado: (2018)

Unified short syntheses of oxygenated tricyclic aromatic diterpenes by radical cyclization with a photoredox catalyst
por: Hashimoto, Riichi, et al.
Publicado: (2023)

Structural determinants of reductive terpene cyclization in iridoid biosynthesis
por: Kries, Hajo, et al.
Publicado: (2015)

Enyne diketones as substrate in asymmetric Nazarov cyclization for construction of chiral allene cyclopentenones
por: Tang, Shengbiao, et al.
Publicado: (2022)

s-Tetrazine-Bridged Photochromic Aromatic Framework Material
por: Chen, Tao, et al.
Publicado: (2022)

Diastereoselective Cascade Cyclization of Diazoimides with Alkylidene Pyrazolones for Preparation of Pyrazole-Fused Oxa-Bridged Oxazocines
por: Wang, Kuo, et al.
Publicado: (2023)

Photocatalytic cyclization of nitrogen-centered radicals with carbon nitride through promoting substrate/catalyst interaction
por: Yang, Mingcheng, et al.
Publicado: (2022)

Intramolecular trapping of spiro radicals to produce unusual cyclization products from usual migration substrates
por: Zhang, Jingming, et al.
Publicado: (2023)

The Rauvolfia tetraphylla genome suggests multiple distinct biosynthetic routes for yohimbane monoterpene indole alkaloids
por: Stander, Emily Amor, et al.
Publicado: (2023)

Meroterpenoid Synthesis via Sequential Polyketide Aromatization and Cationic Polyene Cyclization: Total Syntheses of (+)-Hongoquercin A and B and Related Meroterpenoids
por: Ma, Tsz-Kan, et al.
Publicado: (2018)

Biosynthesis of the Tricyclic Aromatic Type II Polyketide Rishirilide: New Potential Third Ring Oxygenation after Three Cyclization Steps
por: Alali, Ahmad, et al.
Publicado: (2021)

Identification of iridoid synthases from Nepeta species: Iridoid cyclization does not determine nepetalactone stereochemistry
por: Sherden, Nathaniel H., et al.
Publicado: (2018)

Controlling cyclization pathways in palladium(ii)-catalyzed intramolecular alkene hydro-functionalization via substrate directivity
por: Wang, Xin, et al.
Publicado: (2020)

Enhancing Robustness of Sortase A by Loop Engineering and Backbone Cyclization
por: Zou, Zhi, et al.
Publicado: (2020)

Synthesis, optical, and structural properties of bisphenol-bridged aromatic cyclic phosphazenes
por: ÇOŞUT, Bünyemin, et al.
Publicado: (2020)

Bridged Aromatic Oxo‐ and Thioethers with Intense Emission in Solution and the Solid State
por: Riebe, Steffen, et al.
Publicado: (2021)

Meroterpenoid Synthesis via Sequential Polyketide Aromatization and Radical Anion Cascade Triene Cyclization: Biomimetic Total Syntheses of Austalide Natural Products
por: Ma, Tsz-Kan, et al.
Publicado: (2019)

Transition-metal-mediated reduction and reversible double-cyclization of cyanuric triazide to an asymmetric bitetrazolate involving cleavage of the six-membered aromatic ring
por: Vaddypally, Shivaiah, et al.
Publicado: (2020)

Cyclization-Carbonylation-Cyclization Coupling Reaction of Propargyl Ureas with Palladium(II)-Bisoxazoline Catalyst
por: Kusakabe, Taichi, et al.
Publicado: (2012)

Mutagenesis and expression of methane monooxygenase to alter regioselectivity with aromatic substrates
por: Lock, Malcolm, et al.
Publicado: (2017)

Facilitating the Ferration of Aromatic Substrates through Intramolecular Sodium Mediation
por: Maddock, Lewis C. H., et al.
Publicado: (2021)

Characterization of a novel aromatic substrate-processing microcompartment in Actinobacteria
por: Doron, Lior, et al.
Publicado: (2023)

Identifying Genes Involved in Alkaloid Biosynthesis in Vinca minor through Transcriptomics and Gene Co-Expression Analysis
por: Stander, Emily Amor, et al.
Publicado: (2020)

An intermolecular salt bridge linking substrate binding and P1 substrate specificity switch of arterivirus 3C-like proteases
por: Chen, Qian, et al.
Publicado: (2022)

Aromaticity and Extrusion of Benzenoids Linked to [o‐COSAN](−): Clar Has the Answer
por: Poater, Jordi, et al.
Publicado: (2022)

Thermal Stabilization of an Endoglucanase by Cyclization
por: van Lieshout, Johan F. T., et al.
Publicado: (2012)

Cyclization vs. Cyclization/Dimerization in o-Amidostilbene Radical Cation Cascade Reactions: The Amide Question
por: Kee, Chin Hui, et al.
Publicado: (2011)

Aromatic Thioacetal-Bridged ROS-Responsive Nanoparticles as Novel Gene Delivery Vehicles
por: Lin, Guo-Qing, et al.
Publicado: (2018)

A study on the aromatic conjugation pathways and the ring currents of bridged [18]annulenes
por: Tuoheti, Qimanguli, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_gjoi5hsckgrcc7mnfldl94iods