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Expression and purification of a functional heteromeric GABA(A) receptor for structural studies

The GABA-gated chloride channels of the Cys-loop receptor family, known as GABA(A) receptors, function as the primary gatekeepers of fast inhibitory neurotransmission in the central nervous system. Formed by the pentameric arrangement of five identical or homologous subunits, GABA(A) receptor subtyp...

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Detalles Bibliográficos
Autores principales: Claxton, Derek P., Gouaux, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054424/
https://www.ncbi.nlm.nih.gov/pubmed/30028870
http://dx.doi.org/10.1371/journal.pone.0201210