Structure based selection of Human metabolite binding P4 pocket of DRB1*15:01 and DRB1*15:03, with implications for multiple sclerosis

Binding of small molecules in the human leukocyte antigen (HLA) peptide-binding groove may result in conformational changes of bound peptide and an altered immune response, but previous studies have not considered a potential role for endogenous metabolites. We performed virtual screening of the com...

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Detalles Bibliográficos
Autores principales: Misra, Maneesh K., Damotte, Vincent, Hollenbach, Jill A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054566/
https://www.ncbi.nlm.nih.gov/pubmed/29362509
http://dx.doi.org/10.1038/s41435-017-0009-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054566/
https://www.ncbi.nlm.nih.gov/pubmed/29362509
http://dx.doi.org/10.1038/s41435-017-0009-5

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