Abnormal RNA stability in amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) share key features, including accumulation of the RNA-binding protein TDP-43. TDP-43 regulates RNA homeostasis, but it remains unclear whether RNA stability is affected in these disorders. We use Bru-seq and BruChase-seq to assess...

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Detalles Bibliográficos
Autores principales: Tank, E. M., Figueroa-Romero, C., Hinder, L. M., Bedi, K., Archbold, H. C., Li, X., Weskamp, K., Safren, N., Paez-Colasante, X., Pacut, C., Thumma, S., Paulsen, M. T., Guo, K., Hur, J., Ljungman, M., Feldman, E. L., Barmada, S. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054632/
https://www.ncbi.nlm.nih.gov/pubmed/30030424
http://dx.doi.org/10.1038/s41467-018-05049-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054632/
https://www.ncbi.nlm.nih.gov/pubmed/30030424
http://dx.doi.org/10.1038/s41467-018-05049-z

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