Biocompatible, Purified VEGF-A mRNA Improves Cardiac Function after Intracardiac Injection 1 Week Post-myocardial Infarction in Swine

mRNA can direct dose-dependent protein expression in cardiac muscle without genome integration, but to date has not been shown to improve cardiac function in a safe, clinically applicable way. Herein, we report that a purified and optimized mRNA in a biocompatible citrate-saline formulation is tissu...

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Detalles Bibliográficos
Autores principales: Carlsson, Leif, Clarke, Jonathan C., Yen, Christopher, Gregoire, Francine, Albery, Tamsin, Billger, Martin, Egnell, Ann-Charlotte, Gan, Li-Ming, Jennbacken, Karin, Johansson, Edvin, Linhardt, Gunilla, Martinsson, Sofia, Sadiq, Muhammad Waqas, Witman, Nevin, Wang, Qing-Dong, Chen, Chien-Hsi, Wang, Yu-Ping, Lin, Susan, Ticho, Barry, Hsieh, Patrick C.H., Chien, Kenneth R., Fritsche-Danielson, Regina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054703/
https://www.ncbi.nlm.nih.gov/pubmed/30038937
http://dx.doi.org/10.1016/j.omtm.2018.04.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054703/
https://www.ncbi.nlm.nih.gov/pubmed/30038937
http://dx.doi.org/10.1016/j.omtm.2018.04.003

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