Investigation of the key chemical structures involved in the anticancer activity of disulfiram in A549 non-small cell lung cancer cell line

BACKGROUND: Disulfiram (DS), an antialcoholism medicine, demonstrated strong anticancer activity in the laboratory but did not show promising results in clinical trials. The anticancer activity of DS is copper dependent. The reaction of DS and copper generates reactive oxygen species (ROS). After or...

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Detalles Bibliográficos
Autores principales: Butcher, Kate, Kannappan, Vinodh, Kilari, Rajagopal Sharada, Morris, Mark R., McConville, Christopher, Armesilla, Angel L., Wang, Weiguang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054747/
https://www.ncbi.nlm.nih.gov/pubmed/30031402
http://dx.doi.org/10.1186/s12885-018-4617-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054747/
https://www.ncbi.nlm.nih.gov/pubmed/30031402
http://dx.doi.org/10.1186/s12885-018-4617-x

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