Deep sequencing and pathway-focused analysis revealed multigene oncodriver signatures predicting survival outcomes in advanced colorectal cancer

Genomic technologies are reshaping the molecular landscape of colorectal cancer (CRC), revealing that oncogenic driver mutations (APC and TP53) coexist with still underappreciated genetic events. We hypothesized that mutational analysis of CRC-linked genes may provide novel information on the connec...

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Detalles Bibliográficos
Autores principales: De Nicola, Francesca, Goeman, Frauke, Pallocca, Matteo, Sperati, Francesca, Pizzuti, Laura, Melucci, Elisa, Casini, Beatrice, Amoreo, Carla Azzurra, Gallo, Enzo, Diodoro, Maria Grazia, Buglioni, Simonetta, Mazzotta, Marco, Vici, Patrizia, Sergi, Domenico, Di Lauro, Luigi, Barba, Maddalena, Pescarmona, Edoardo, Ciliberto, Gennaro, De Maria, Ruggero, Fanciulli, Maurizio, Maugeri-Saccà, Marcello
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054833/
https://www.ncbi.nlm.nih.gov/pubmed/30032163
http://dx.doi.org/10.1038/s41389-018-0066-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054833/
https://www.ncbi.nlm.nih.gov/pubmed/30032163
http://dx.doi.org/10.1038/s41389-018-0066-2

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