Type-I Interferons Inhibit Interleukin-10 Signaling and Favor Type 1 Diabetes Development in Nonobese Diabetic Mice

Destruction of insulin-producing β-cells by autoreactive T lymphocytes leads to the development of type 1 diabetes. Type-I interferons (TI-IFN) and interleukin-10 (IL-10) have been connected with the pathophysiology of this disease; however, their interplay in the modulation of diabetogenic T cells...

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Detalles Bibliográficos
Autores principales: Iglesias, Marcos, Arun, Anirudh, Chicco, Maria, Lam, Brandon, Talbot, C. Conover, Ivanova, Vera, Lee, W. P. A., Brandacher, Gerald, Raimondi, Giorgio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054963/
https://www.ncbi.nlm.nih.gov/pubmed/30061883
http://dx.doi.org/10.3389/fimmu.2018.01565

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054963/
https://www.ncbi.nlm.nih.gov/pubmed/30061883
http://dx.doi.org/10.3389/fimmu.2018.01565

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