Synthesis, Characterization, Cytotoxicity, and Antibacterial Properties of trans‐γ‐Halo‐δ‐lactones

A new four‐step pathway for the synthesis of γ‐halo‐δ‐lactones is described from simple, commercially available substrates: aryl bromides and 3‐methyl crotonaldehyde. The halogenolactonization reaction of β,δ‐substituted, γ,δ‐unsaturated carboxylic acid 4 a–c is regio‐ and stereoselective and gives...

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Detalles Bibliográficos
Autores principales: Kamizela, Angelika, Gawdzik, Barbara, Urbaniak, Mariusz, Lechowicz, Łukasz, Białońska, Agata, Gonciarz, Weronika, Chmiela, Magdalena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6055027/
https://www.ncbi.nlm.nih.gov/pubmed/30038879
http://dx.doi.org/10.1002/open.201800110

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6055027/
https://www.ncbi.nlm.nih.gov/pubmed/30038879
http://dx.doi.org/10.1002/open.201800110

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