Hypoxia inducible factor 2α (HIF2α/EPAS1) is associated with development of pulmonary hypertension in severe congenital diaphragmatic hernia patients

We show that hypoxia inducible factor 2α (HIF2α) is highly expressed in patients with pulmonary hypertension (PH). HIF2α is expressed in every patient with congenital diaphragmatic hernia, while only half of the controls express HIF2α. Our data suggest that HIF2α is a link between hypoxia and the de...

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Autores principales: Huang, Yadi, Boerema-de Munck, Anne, Buscop-van Kempen, Marjon, Sluiter, Ilona, de Krijger, Ronald, Tibboel, Dick, Rottier, Robbert J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2018
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6055252/
https://www.ncbi.nlm.nih.gov/pubmed/29855254
http://dx.doi.org/10.1177/2045894018783734
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author Huang, Yadi
Boerema-de Munck, Anne
Buscop-van Kempen, Marjon
Sluiter, Ilona
de Krijger, Ronald
Tibboel, Dick
Rottier, Robbert J.
author_facet Huang, Yadi
Boerema-de Munck, Anne
Buscop-van Kempen, Marjon
Sluiter, Ilona
de Krijger, Ronald
Tibboel, Dick
Rottier, Robbert J.
author_sort Huang, Yadi
collection PubMed
description We show that hypoxia inducible factor 2α (HIF2α) is highly expressed in patients with pulmonary hypertension (PH). HIF2α is expressed in every patient with congenital diaphragmatic hernia, while only half of the controls express HIF2α. Our data suggest that HIF2α is a link between hypoxia and the development of PH.
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spelling pubmed-60552522018-07-25 Hypoxia inducible factor 2α (HIF2α/EPAS1) is associated with development of pulmonary hypertension in severe congenital diaphragmatic hernia patients Huang, Yadi Boerema-de Munck, Anne Buscop-van Kempen, Marjon Sluiter, Ilona de Krijger, Ronald Tibboel, Dick Rottier, Robbert J. Pulm Circ Research Letter We show that hypoxia inducible factor 2α (HIF2α) is highly expressed in patients with pulmonary hypertension (PH). HIF2α is expressed in every patient with congenital diaphragmatic hernia, while only half of the controls express HIF2α. Our data suggest that HIF2α is a link between hypoxia and the development of PH. SAGE Publications 2018-06-01 /pmc/articles/PMC6055252/ /pubmed/29855254 http://dx.doi.org/10.1177/2045894018783734 Text en © The Author(s) 2018 http://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Research Letter
Huang, Yadi
Boerema-de Munck, Anne
Buscop-van Kempen, Marjon
Sluiter, Ilona
de Krijger, Ronald
Tibboel, Dick
Rottier, Robbert J.
Hypoxia inducible factor 2α (HIF2α/EPAS1) is associated with development of pulmonary hypertension in severe congenital diaphragmatic hernia patients
title Hypoxia inducible factor 2α (HIF2α/EPAS1) is associated with development of pulmonary hypertension in severe congenital diaphragmatic hernia patients
title_full Hypoxia inducible factor 2α (HIF2α/EPAS1) is associated with development of pulmonary hypertension in severe congenital diaphragmatic hernia patients
title_fullStr Hypoxia inducible factor 2α (HIF2α/EPAS1) is associated with development of pulmonary hypertension in severe congenital diaphragmatic hernia patients
title_full_unstemmed Hypoxia inducible factor 2α (HIF2α/EPAS1) is associated with development of pulmonary hypertension in severe congenital diaphragmatic hernia patients
title_short Hypoxia inducible factor 2α (HIF2α/EPAS1) is associated with development of pulmonary hypertension in severe congenital diaphragmatic hernia patients
title_sort hypoxia inducible factor 2α (hif2α/epas1) is associated with development of pulmonary hypertension in severe congenital diaphragmatic hernia patients
topic Research Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6055252/
https://www.ncbi.nlm.nih.gov/pubmed/29855254
http://dx.doi.org/10.1177/2045894018783734
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