Biocatalytic Conversion of Cyclic Ketones Bearing α‐Quaternary Stereocenters into Lactones in an Enantioselective Radical Approach to Medium‐Sized Carbocycles

Cyclic ketones bearing α‐quaternary stereocenters underwent efficient kinetic resolution using cyclohexanone monooxygenase (CHMO) from Acinetobacter calcoaceticus. Lactones possessing tetrasubstituted stereocenters were obtained with high enantioselectivity (up to >99 % ee) and complete chemosele...

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Detalles Bibliográficos
Autores principales: Morrill, Charlotte, Jensen, Chantel, Just‐Baringo, Xavier, Grogan, Gideon, Turner, Nicholas J., Procter, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6055628/
https://www.ncbi.nlm.nih.gov/pubmed/29393988
http://dx.doi.org/10.1002/anie.201800121

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6055628/
https://www.ncbi.nlm.nih.gov/pubmed/29393988
http://dx.doi.org/10.1002/anie.201800121

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