Hepatic PPARα function is controlled by polyubiquitination and proteasome‐mediated degradation through the coordinated actions of PAQR3 and HUWE1

Peroxisome proliferator‐activated receptor α (PPARα) is a key transcriptional factor that regulates hepatic lipid catabolism by stimulating fatty acid oxidation and ketogenesis in an adaptive response to nutrient starvation. However, how PPARα is regulated by posttranslational modification is poorly...

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Detalles Bibliográficos
Autores principales: Zhao, Zilong, Xu, Daqian, Wang, Zheng, Wang, Lin, Han, Ruomei, Wang, Zhenzhen, Liao, Lujian, Chen, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6055728/
https://www.ncbi.nlm.nih.gov/pubmed/29331071
http://dx.doi.org/10.1002/hep.29786

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6055728/
https://www.ncbi.nlm.nih.gov/pubmed/29331071
http://dx.doi.org/10.1002/hep.29786

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