Infection with a Brazilian isolate of Zika virus generates RIG‐I stimulatory RNA and the viral NS5 protein blocks type I IFN induction and signaling

Zika virus (ZIKV) is a major public health concern in the Americas. We report that ZIKV infection and RNA extracted from ZIKV infected cells potently activated the induction of type I interferons (IFNs). This effect was fully dependent on the mitochondrial antiviral signaling protein (MAVS), implica...

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Detalles Bibliográficos
Autores principales: Hertzog, Jonny, Dias Junior, Antonio Gregorio, Rigby, Rachel E., Donald, Claire L., Mayer, Alice, Sezgin, Erdinc, Song, Chaojun, Jin, Boquan, Hublitz, Philip, Eggeling, Christian, Kohl, Alain, Rehwinkel, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Innate immunity
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6055886/
https://www.ncbi.nlm.nih.gov/pubmed/29572905
http://dx.doi.org/10.1002/eji.201847483

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6055886/
https://www.ncbi.nlm.nih.gov/pubmed/29572905
http://dx.doi.org/10.1002/eji.201847483

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