BRD4 amplification facilitates an oncogenic gene expression program in high-grade serous ovarian cancer and confers sensitivity to BET inhibitors

BRD4 is a transcriptional co-activator functioning to recruit regulatory complexes to acetylated chromatin. A subset of High-grade Serous Ovarian Cancer (HGSOC) patients are typified by focal, recurrent BRD4 gene amplifications. Despite previously described cancer dependencies, it is unclear whether...

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Detalles Bibliográficos
Autores principales: Rhyasen, Garrett W., Yao, Yi, Zhang, Jingwen, Dulak, Austin, Castriotta, Lillian, Jacques, Kelly, Zhao, Wei, Gharahdaghi, Farzin, Hattersley, Maureen M., Lyne, Paul D., Clark, Edwin, Zinda, Michael, Fawell, Stephen E., Mills, Gordon B., Chen, Huawei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056044/
https://www.ncbi.nlm.nih.gov/pubmed/30036377
http://dx.doi.org/10.1371/journal.pone.0200826

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056044/
https://www.ncbi.nlm.nih.gov/pubmed/30036377
http://dx.doi.org/10.1371/journal.pone.0200826

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