Achilles and tail tendons of perlecan exon 3 null heparan sulphate deficient mice display surprising improvement in tendon tensile properties and altered collagen fibril organisation compared to C57BL/6 wild type mice

The aim of this study was to determine the role of the perlecan (Hspg2) heparan sulphate (HS) side chains on cell and matrix homeostasis in tail and Achilles tendons in 3 and 12 week old Hspg2 exon 3 null HS deficient (Hspg2(Δ3 − ∕Δ3 −)) and C57 BL/6 Wild Type (WT) mice. Perlecan has important cell...

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Detalles Bibliográficos
Autores principales: Shu, Cindy C., Smith, Margaret M., Appleyard, Richard C., Little, Christopher B., Melrose, James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2018
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056265/
https://www.ncbi.nlm.nih.gov/pubmed/30042881
http://dx.doi.org/10.7717/peerj.5120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056265/
https://www.ncbi.nlm.nih.gov/pubmed/30042881
http://dx.doi.org/10.7717/peerj.5120

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