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The conformational wave in capsaicin activation of transient receptor potential vanilloid 1 ion channel

The capsaicin receptor TRPV1 has been intensively studied by cryo-electron microscopy and functional tests. However, though the apo and capsaicin-bound structural models are available, the dynamic process of capsaicin activation remains intangible, largely due to the lack of a capsaicin-induced open...

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Detalles Bibliográficos
Autores principales: Yang, Fan, Xiao, Xian, Lee, Bo Hyun, Vu, Simon, Yang, Wei, Yarov-Yarovoy, Vladimir, Zheng, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056546/
https://www.ncbi.nlm.nih.gov/pubmed/30038260
http://dx.doi.org/10.1038/s41467-018-05339-6